3-Methoxy-5-isoxazolemethanamine → 4-(3-chloro-4-methylphenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide

HRID 1528475Notes

Reaction equation

HRID 1528475 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:14]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:13][N:12]=[C:11]([C:21](O)=[O:22])[CH:10]=2)[CH:5]=[CH:6][C:7]=1[CH3:8].[CH3:24][O:25][C:26]1[CH:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:14]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:13][N:12]=[C:11]([C:21]([NH:32][CH2:31][C:29]3[O:28][N:27]=[C:26]([O:25][CH3:24])[CH:30]=3)=[O:22])[CH:10]=2)[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 27632273-Methoxy-5-isoxazolemethanamineHCID 666788394-(3-Chloro-4-methylphenyl)-5-(2,2,2-trifluoroethoxy)picolinic acid

Product 1

HCID 569291864-(3-chloro-4-methylphenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide

Procedure

The title compound was synthesized in analogy to Example 1 using 4-(3-chloro-4-methylphenyl)-5-(2,2,2-trifluoroethoxy)picolinic acid (example BM) and 3-methoxy-5-isoxazolemethanamine (CAN 2763-94-2) as starting materials; LC-MS (UV peak area/ESI) 100%, 456.0934 (M+H)+.

Sources & evidence

ORD record
ord-9d62d1beada94db18d52d435903dd8b8
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

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