(2-Cyclopropylthiazol-4-yl)methanamine → 4-(4-chloro-3-methylphenyl)-N-((2-cyclopropylthiazol-4-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=[C:10]([C:20](O)=[O:21])[CH:9]=2)=[CH:4][C:3]=1[CH3:23].[CH:24]1([C:27]2[S:28][CH:29]=[C:30]([CH2:32][NH2:33])[N:31]=2)[CH2:26][CH2:25]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:12][N:11]=[C:10]([C:20]([NH:33][CH2:32][C:30]3[N:31]=[C:27]([CH:24]4[CH2:26][CH2:25]4)[S:28][CH:29]=3)=[O:21])[CH:9]=2)=[CH:4][C:3]=1[CH3:23]Participants
3
Procedure
The title compound was synthesized in analogy to Example 1 using 4-(4-chloro-3-methylphenyl)-5-(2,2,2-trifluoroethoxy)picolinic acid (example BN) and 2-cyclopropyl-4-thiazolemethanamine (CAN 1083299-53-9) as starting materials; LC-MS (UV peak area/ESI) 100%, 482.0911 (M+H)+.
Sources & evidence
- ORD record
- ord-1825c677bb3c4ca6b480206d6ab3e7a5
- Source dataset
- uspto-grants-2015_07
- Patent number
- US09090599B2
Reaction notes
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