(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine → 5-(4-ethylphenyl)-6-(2,2,2-trifluoroethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide

HRID 1528485Notes

Reaction equation

HRID 1528485 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[N:11][CH:12]=[C:13]([CH:17]=2)[C:14](O)=[O:15])=[CH:5][CH:4]=1)[CH3:2].[F:24][C:25]([F:34])([F:33])[C:26]1[N:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=1>>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:10]([O:18][CH2:19][C:20]([F:23])([F:21])[F:22])=[N:11][CH:12]=[C:13]([CH:17]=2)[C:14]([NH:32][CH2:31][C:29]2[O:28][N:27]=[C:26]([C:25]([F:34])([F:33])[F:24])[N:30]=2)=[O:15])=[CH:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 55263061(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamineHCID 666784865-(4-Ethylphenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 569293715-(4-ethylphenyl)-6-(2,2,2-trifluoroethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(4-ethylphenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid (example BS) and 3-trifluoromethyl-[1,2,4]oxadiazol-5-methanamine (example AK) as starting materials; LC-MS (UV peak area/ESI) 100%, 473.1054 (M−H)−.

Sources & evidence

ORD record
ord-d5bfd55a03c04a3aafebec25d6a86694
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

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