(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine → HCID 56929372, compound

HRID 1528486Notes

Reaction equation

HRID 1528486 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:22])([F:21])[F:20])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([OH:15])=O)=[C:4]([F:23])[CH:3]=1.[F:24][C:25]([F:34])([F:33])[C:26]1[N:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:21])([F:20])[F:22])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([NH:32][CH2:31][C:29]2[O:28][N:27]=[C:26]([C:25]([F:34])([F:33])[F:24])[N:30]=2)=[O:15])=[C:4]([F:23])[CH:3]=1

Participants

3

Reactant 2

HCID 55263061(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamineHCID 66678488HCID 66678488, compound

Product 1

HCID 56929372HCID 56929372, compound

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(4-chloro-2-fluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid (example BT) and 3-trifluoromethyl-[1,2,4]oxadiazol-5-methanamine (example AK) as starting materials; LC-MS (UV peak area/ESI) 98.6%, 497.0254 (M−H)−.

Sources & evidence

ORD record
ord-44efebfa5103465dbc53e1840f85344f
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

Loading…