HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxy-5-isoxazolemethanamine → 5-(4-chloro-3-fluorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-6-(2,2,2-trifluoroethoxy)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxy-5-isoxazolemethanamine | HCID 2763227 | — |
| Reactant | 5-(4-Chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid | HCID 66678612 | — |
| Product | 5-(4-chloro-3-fluorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-6-(2,2,2-trifluoroethoxy)nicotinamide | HCID 56929374 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1 using 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid (example BR) and 3-methoxy-5-isoxazolemethanamine (CAN 2763-94-2) as starting materials; LC-MS (UV peak area/ESI) 100%, 458.0537 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090599B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-deea9c291f9c44778eb6d4c0f99d5474 |
| Source note | uspto-grants-2015_07 |