(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine → 5-(4-chlorophenyl)-6-cyclobutoxy-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide

HRID 1528494Notes

Reaction equation

HRID 1528494 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH:18]3[CH2:21][CH2:20][CH2:19]3)=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13](O)=[O:14])=[CH:4][CH:3]=1.[F:22][C:23]([F:32])([F:31])[C:24]1[N:28]=[C:27]([CH2:29][NH2:30])[O:26][N:25]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH:18]3[CH2:19][CH2:20][CH2:21]3)=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([NH:30][CH2:29][C:27]2[O:26][N:25]=[C:24]([C:23]([F:32])([F:31])[F:22])[N:28]=2)=[O:14])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 55263061(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamineHCID 666786185-(4-Chlorophenyl)-6-cyclobutoxy-nicotinic acid

Product 1

HCID 666788185-(4-chlorophenyl)-6-cyclobutoxy-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(4-chlorophenyl)-6-cyclobutoxy-nicotinic acid (example CA) and 3-trifluoromethyl-[1,2,4]oxadiazol-5-methanamine (example AK) as starting materials; LC-MS (UV peak area/ESI) 92.8%, 451.1 (M−H)−.

Sources & evidence

ORD record
ord-95ea965702314773b993951dd61921f2
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

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