(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine → HCID 56929664, compound

HRID 1528502Notes

Reaction equation

HRID 1528502 reaction equation
[N:1]1[O:5][N:4]=[C:3]2[CH:6]=[C:7]([C:10]3[C:11]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[N:12][CH:13]=[C:14]([CH:18]=3)[C:15](O)=[O:16])[CH:8]=[CH:9][C:2]=12.[F:25][C:26]([F:35])([F:34])[C:27]1[N:31]=[C:30]([CH2:32][NH2:33])[O:29][N:28]=1>>[N:1]1[O:5][N:4]=[C:3]2[CH:6]=[C:7]([C:10]3[C:11]([O:19][CH2:20][C:21]([F:23])([F:24])[F:22])=[N:12][CH:13]=[C:14]([CH:18]=3)[C:15]([NH:33][CH2:32][C:30]3[O:29][N:28]=[C:27]([C:26]([F:35])([F:34])[F:25])[N:31]=3)=[O:16])[CH:8]=[CH:9][C:2]=12

Participants

3

Reactant 2

HCID 55263061(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamineHCID 66678872HCID 66678872, compound

Product 1

HCID 56929664HCID 56929664, compound

Procedure

The title compound was synthesized in analogy to Example 1 using 5-benzo[1,2,5]oxadiazol-5-yl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (example CH) and 3-trifluoromethyl-[1,2,4]oxadiazol-5-methanamine (example AK) as starting materials; MS (ESI) 489.2 (M+H)+.

Sources & evidence

ORD record
ord-b1b31caba40141c4b1a6d60196f7b820
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

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