HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoxazole → 2-(4-Methylbenzoxazolyl)-5-(hydroxylmethyl)-1,4-bis(hexyloxy)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoxazole | HCID 9228 | — |
| Reactant | 2-Amino-4-tert-butylphenol | HCID 70982 | — |
| Reactant | 2-Amino-m-cresol | HCID 3014138 | — |
| Reactant | 2,5-Bis(hexyloxy)-4-(hydroxymethyl)benzaldehyde | HCID 86712492 | — |
| Reactant | 4-(4-Methylbenzoxazolyl)-2,5-bis(hexyloxy)benzaldehyde | HCID 90005984 | — |
| Product | 2-(4-Methylbenzoxazolyl)-5-(hydroxylmethyl)-1,4-bis(hexyloxy)benzene | HCID 86712491 | 71% |
Reaction Steps
The sensor Zinhbo-5 can be synthesized as shown in Scheme 1, which requires a sequential construction of two benzoxazole units. The first benzoxazole unit is constructed by reaction of 2-amino-m-cresol with 2,5-bis(hexyloxy)-4-(hydroxymethyl)benzaldehyde in three steps (in 71% yield). The second benzoxazole unit is synthesized by reaction of 2-amino-4-(tert-butyl)phenol with 4-(4-methylbenzoxazolyl)-2,5-bis(hexyloxy)benzaldehyde.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090602B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-8330dbbe449f465ea4cac4a869e01603 |
| Source note | uspto-grants-2015_07 |