HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dibromoethane → 1-(6-Bromopyridin-2-YL)cyclopropane-1-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dibromoethane | HCID 7839 | — |
| Reactant | Ethyl 2-(6-bromopyridin-2-yl)acetate | HCID 53419420 | — |
| Product | 1-(6-Bromopyridin-2-YL)cyclopropane-1-carboxylic acid | HCID 72211995 | 57% |
Reaction Steps
The title compound was prepared from (6-bromo-pyridin-2-yl)-acetic acid ethyl ester and 1,2-dibromoethane following a procedure analogous to that described in Step 3 for Intermediate 4; under these conditions the ester group was hydrolyzed. Yield: 57% of theory; LC (method 3): tR=2.60 min; Mass spectrum (ESI+): m/z=242/244 (Br) [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090605B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-8a41f52ea8354164931c5bdd93017cb9 |
| Source note | uspto-grants-2015_07 |