HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one → HCID 70652030, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one | HCID 59532385 | — |
| Reactant | 1-(6-Chloro-3-pyridinyl)cyclopropanecarboxamide | HCID 71743267 | — |
| Product | HCID 70652030 | HCID 70652030 | 47% |
Reaction Steps
The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-{(S)-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-ethyl}-1,3-oxazinan-2-one and 1-(6-chloro-pyridin-3-yl)-cyclopropanecarboxylic acid amide following a procedure analogous to that described in Example 1. Yield: 47% of theory; LC (method 1): tR=1.85 min; Mass spectrum (ESI+): m/z=514 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090605B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-3ce296f7b0144582a88359f60cbd3e51 |
| Source note | uspto-grants-2015_07 |