反应详情

A suspension of 5.00 g (31.4 mmol) of 3,5-difluoropyridine-2-carboxylic acid in thionyl chloride (21 ml) was heated to reflux for 5 h. The solution was concentrated, and the residue was twice taken up in a little toluene and concentrated again. This gave 3.80 g of a solid, which was reacted further directly without further purification.

1. temperaturewas heated
2. temperatureto reflux for 5 h
3. concentrationThe solution was concentrated
4. concentrationconcentrated again
5. customThis gave 3.80 g of a solid, which was reacted further directly without further purification