HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5-(4-Bromophenyl)-3-methylisoxazol-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate | HCID 66577242 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(4-Bromophenyl)-3-methylisoxazol-4-amine | HCID 58218537 | — |
Reaction Steps
[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-carbamic acid tert-butyl ester (0.38 g, 1.07 mmol) was treated with 50% trifluoroacetic acid in CH2Cl2 and stirred for 3 hours. Once no starting material was seen by analytical LCMS, the mixture was concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090573B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-ce73017e351f42a0a9fb64e6e3ee1326 |
| Source note | uspto-grants-2015_07 |