(R)-(+)-1-Phenylethyl isocyanate → HCID 66577970, compound

HRID 1528718Notes

Reaction equation

HRID 1528718 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH2:14][OH:15])=[CH:4][CH:3]=1.[CH3:16][C@@H:17]([N:24]=[C:25]=[O:26])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C1(C)C=CC=CC=1.C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH2:14][O:15][C:25](=[O:26])[NH:24][C@@H:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:16])=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 7018262(R)-(+)-1-Phenylethyl isocyanateHCID 58218538[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol

Product 1

HCID 66577970HCID 66577970, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
90 °C

Procedure

[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol (0.120 g, 0.45 mmol) and (R)-(+)-α-methylbenzyl isocyanate (0.17 mL, 1.2 mmol) were combined in toluene and stirred overnight at 90° C. The mixture was diluted with CH2Cl2 and purified by silica gel chromatography to give the title compound.

Workup

  1. custompurified by silica gel chromatography

Sources & evidence

ORD record
ord-b2310515cbe847d388e469af3949569f
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

Loading…