Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylate → HCID 66578037, compound

HRID 1528739Notes

Reaction equation

HRID 1528739 reaction equation
[CH2:1]([NH:8][CH2:9][C:10]1[C:11]([CH3:22])=[N:12][O:13][C:14]=1[C:15]1[CH:20]=[CH:19][C:18](Br)=[CH:17][CH:16]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:23]([O:25][C:26]([C:28]1([C:31]2[CH:36]=[CH:35][C:34](B3OC(C)(C)C(C)(C)O3)=[CH:33][CH:32]=2)[CH2:30][CH2:29]1)=[O:27])[CH3:24]>>[CH2:23]([O:25][C:26]([C:28]1([C:31]2[CH:36]=[CH:35][C:34]([C:18]3[CH:19]=[CH:20][C:15]([C:14]4[O:13][N:12]=[C:11]([CH3:22])[C:10]=4[CH2:9][NH:8][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)=[CH:16][CH:17]=3)=[CH:33][CH:32]=2)[CH2:29][CH2:30]1)=[O:27])[CH3:24]

Participants

3

Reactant 2

HCID 53217182Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylateHCID 66578224HCID 66578224, compound

Product 1

HCID 66578037HCID 66578037, compound

Procedure

Prepared according to the procedure described in Example 3, Step 5, using benzyl-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylmethyl]-amine and 1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e3d6cdc6d92f4a5e86b8b308a47f8f10
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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