2-Fluoro-N-methylbenzylamine → 1-[4'-(4-{2-[(2-Fluoro-benzyl)-methyl-carbamoyl]-ethyl}-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

HRID 1528767Notes

Reaction equation

HRID 1528767 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[CH2:27][CH2:28][C:29]([OH:31])=O)=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[F:32][C:33]1[CH:41]=[CH:40][CH:39]=[CH:38][C:34]=1[CH2:35][NH:36][CH3:37]>>[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:16]=[CH:17][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[CH2:27][CH2:28][C:29](=[O:31])[N:36]([CH2:35][C:34]4[CH:38]=[CH:39][CH:40]=[CH:41][C:33]=4[F:32])[CH3:37])=[CH:19][CH:20]=3)=[CH:13][CH:14]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 20608422-Fluoro-N-methylbenzylamineHCID 665772681-{4'-[4-(2-Carboxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

Product 1

HCID 665781611-[4'-(4-{2-[(2-Fluoro-benzyl)-methyl-carbamoyl]-ethyl}-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 33, Step 4, using 1-{4′-[4-(2-carboxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester and 2-fluoro-N-methylbenzylamine.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0541123396864b30bcb8fb75b9194c84
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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