(2-Chlorophenyl)methanesulfonyl chloride → HCID 66578776, compound

HRID 1528789Notes

Reaction equation

HRID 1528789 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[CH2:27][NH2:28])=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[Cl:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[CH2:36][S:37](Cl)(=[O:39])=[O:38]>>[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[CH2:27][NH:28][S:37]([CH2:36][C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=4[Cl:29])(=[O:38])=[O:39])=[CH:17][CH:16]=3)=[CH:13][CH:14]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 2757801(2-Chlorophenyl)methanesulfonyl chlorideHCID 66578532HCID 66578532, compound

Product 1

HCID 66578776HCID 66578776, compound

Procedure

Prepared according to the procedure described in Example 3, Step 7, using 1-[4′-(4-aminomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester and (2-chloro-phenyl)-methanesulfonyl chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b375698c3d5141cf8cb02081bcfa1d50
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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