Isoindoline → 2-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-1-(1,3-dihydro-isoindol-2-yl)-ethanone

HRID 1528793Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH2:14][C:15]([OH:17])=O)=[CH:4][CH:3]=1.[CH2:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20][NH:19]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH2:14][C:15]([N:19]2[CH2:20][C:21]3[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:18]2)=[O:17])=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 422478Isoindoline

HCID 66577233[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]acetic acid

Product 1

HCID 665785162-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-1-(1,3-dihydro-isoindol-2-yl)-ethanone

Procedure

Prepared according to the procedure described in Example 33, Step 4, using [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetic acid and 2,3-dihydro-1H-isoindole.

Workup

customPrepared

Sources & evidence

ORD record: ord-9be0b775964c4aab81388a65c495e39f
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09090573B2

Reaction notes

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