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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1528813Generated: October 31, 2026

alpha-Bromo-o-chlorotoluene → 1-(4'-{4-[2-(2-Chloro-benzyloxy)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

https://huagongshe.com/reaction/1528813

Reaction equation

Participants

RoleNameHCIDCharge
Reactantalpha-Bromo-o-chlorotolueneHCID 11905—
Reactant1-{4'-[4-(2-Hydroxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl esterHCID 66577266—
Product1-(4'-{4-[2-(2-Chloro-benzyloxy)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acidHCID 51352435—

Reaction Steps

Prepared according to the procedure described in Example 34, Step 4, using 1-{4′-[4-(2-hydroxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester and 1-bromomethyl-2-chloro-benzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09090573B2
Source datasetuspto-grants-2015_07
ORD IDord-da0f2f48f89a4f64b5f1872f54018e8b
Source noteuspto-grants-2015_07