Phosphorus tribromide → 1-Bromo-4-[1-(bromomethyl)cyclopropyl]benzene

HRID 1528835Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:11]O)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.P(Br)(Br)[Br:14]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:11][Br:14])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 24614Phosphorus tribromide

HCID 20252945(1-(4-Bromophenyl)cyclopropyl)methanol

Product 1

HCID 665783561-Bromo-4-[1-(bromomethyl)cyclopropyl]benzene

Procedure

Prepared according to the procedure described in Example 33, Step 1, using [1-(4-bromo-phenyl)-cyclopropyl]-methanol and phosphorus tribromide.

Workup

customPrepared

Sources & evidence

ORD record: ord-25420be4a25b44beb7545874a6898738
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09090573B2

Reaction notes

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