HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → 2-[1-(4-Bromophenyl)cyclopropyl]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-[1-(4-Bromophenyl)cyclopropyl]acetonitrile | HCID 66579314 | — |
| Product | 2-[1-(4-Bromophenyl)cyclopropyl]acetic acid | HCID 66577622 | — |
Reaction Conditions
| Temperature | 180 °C |
|---|
Reaction Steps
[1-(4-Bromo-phenyl)-cyclopropyl]-acetonitrile (3.95 g, 16.73 mmol) and potassium hydroxide (3.75 g, 66.92 mmol) were combined in ethylene glycol (24 mL) and stirred at 180° C. overnight. The mixture was acidified with 6 N aqueous HCl and extracted three times with EtOAc. The combined organic layers were dried and concentrated to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090573B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-81148ddb96b94b83b122698b55ca8e24 |
| Source note | uspto-grants-2015_07 |