Methyl iodide → HCID 66578334, compound

HRID 1528860Notes

Reaction equation

[CH:1]1([CH2:4][NH:5][C:6]([CH2:8][CH2:9][C:10]2[C:11]([CH3:33])=[N:12][O:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][C:24]([C:27]4([C:30]([OH:32])=[O:31])[CH2:29][CH2:28]4)=[CH:23][CH:22]=3)=[CH:17][CH:16]=2)=[O:7])[CH2:3][CH2:2]1.I[CH3:35]>>[CH:1]1([CH2:4][N:5]([CH3:35])[C:6]([CH2:8][CH2:9][C:10]2[C:11]([CH3:33])=[N:12][O:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:22]=[CH:23][C:24]([C:27]4([C:30]([OH:32])=[O:31])[CH2:28][CH2:29]4)=[CH:25][CH:26]=3)=[CH:17][CH:16]=2)=[O:7])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 66578612HCID 66578612, compound

Product 1

HCID 66578334HCID 66578334, compound

Procedure

Prepared according to the procedure described in Example 34, Step 4, using 1-(4′-{4-[2-(cyclopropylmethyl-carbamoyl)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid and iodomethane.

Workup

customPrepared

Sources & evidence

ORD record: ord-ce1331ab79e044a18b379ef0830c5d62
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09090573B2

Reaction notes

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