HCID 66577258, compound → HCID 51351852, compound

HRID 1528871Notes

Reaction equation

HRID 1528871 reaction equation
[CH3:1][C:2]1[C:6]([C:7](=[O:17])[CH2:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:5]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30]4([C:33]([OH:35])=[O:34])[CH2:32][CH2:31]4)=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)[O:4][N:3]=1.[CH3:36][Mg]I>>[OH:17][C:7]([C:6]1[C:2]([CH3:1])=[N:3][O:4][C:5]=1[C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]3([C:33]([OH:35])=[O:34])[CH2:32][CH2:31]3)=[CH:28][CH:29]=2)=[CH:20][CH:19]=1)([CH3:36])[CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 66577258HCID 66577258, compoundHCID 178418373HCID 178418373, compound

Product 1

HCID 51351852HCID 51351852, compound

Procedure

Prepared according to the procedure described in Example 114, Step 3, using 1-{4′-[3-methyl-4-(4-phenyl-butyryl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid and methylmagnesium iodide.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-afd7a3b0c155449bac660328cb9fd6e4
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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