Methyl iodide → HCID 66578590, compound

HRID 1528872Notes

Reaction equation

[CH:1]1([NH:4][C:5]([CH2:7][CH2:8][C:9]2[C:10]([CH3:32])=[N:11][O:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][C:23]([C:26]4([C:29]([OH:31])=[O:30])[CH2:28][CH2:27]4)=[CH:22][CH:21]=3)=[CH:16][CH:15]=2)=[O:6])[CH2:3][CH2:2]1.I[CH3:34]>>[CH:1]1([N:4]([CH3:34])[C:5]([CH2:7][CH2:8][C:9]2[C:10]([CH3:32])=[N:11][O:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][C:23]([C:26]4([C:29]([OH:31])=[O:30])[CH2:28][CH2:27]4)=[CH:22][CH:21]=3)=[CH:16][CH:15]=2)=[O:6])[CH2:2][CH2:3]1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 66578277HCID 66578277, compound

Product 1

HCID 66578590HCID 66578590, compound

Procedure

Prepared according to the procedure described in Example 34, Step 4, using 1-{4′-[4-(2-Cyclopropylcarbamoyl-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid and iodomethane.

Workup

customPrepared

Sources & evidence

ORD record: ord-c7172c65978e4277a5887083aa97568c
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09090573B2

Reaction notes

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