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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1528906Generated: October 25, 2026

4-[3-(Trifluoromethyl)phenyl]butan-2-one → 1-(4'-{3-Methyl-4-[1-methyl-3-(3-trifluoromethyl-phenyl)-propylamino]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid ethyl ester

https://huagongshe.com/reaction/1528906

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-[3-(Trifluoromethyl)phenyl]butan-2-oneHCID 13339059—
Reactant1-[4'-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl esterHCID 66577195—
Product1-(4'-{3-Methyl-4-[1-methyl-3-(3-trifluoromethyl-phenyl)-propylamino]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid ethyl esterHCID 66581771—

Reaction Steps

Prepared according to the procedure described in Example 24, Step 1, using 1-[4′-(4-amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester and 4-(3-trifluoromethyl-phenyl)-butan-2-one.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09090573B2
Source datasetuspto-grants-2015_07
ORD IDord-8444b0f9401e41b2b93506808d23c56d
Source noteuspto-grants-2015_07