HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde → 1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-4-phenyl-butan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde | HCID 82133792 | — |
| Reactant | HCID 178418471 | HCID 178418471 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-4-phenyl-butan-1-ol | HCID 66578445 | — |
Reaction Steps
Prepared according to the procedure described in Example 114, Step 3, using 5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde and 3-(phenyl)propylmagnesium bromide. After the reaction the material was submitted to chiral preparatory HPLC (Chiralcel AS Column, 2% EtOH in hexanes, 60 minute run). The first enantiomer off of the column is Enantiomer A.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090573B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-48aff62592ce48618c0001853992d8b3 |
| Source note | uspto-grants-2015_07 |