HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1528946Generated: October 26, 2026
1-Aminoindane, (S)- → 1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-2-((S)-indan-1-ylamino)-ethanol
https://huagongshe.com/reaction/1528946
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Aminoindane, (S)- | HCID 7000084 | — |
| Reactant | 5-(4-Bromo-phenyl)-3-methyl-4-oxiranyl-isoxazole | HCID 86652404 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-2-((S)-indan-1-ylamino)-ethanol | HCID 66578694 | — |
Reaction Steps
5-(4-Bromo-phenyl)-3-methyl-4-oxiranyl-isoxazole (0.180 g, 0.64 mmol) and (S)-indan-1-ylamine (0.171 g, 1.29 mmol) were mixed in N-methylpyrrolidone (4.0 mL) and then heated to 85° C. over 2 nights while monitoring with analytical LCMS. The reaction was submitted to standard aqueous workup then purified via preparatory HPLC to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09090573B2 |
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| Source dataset | uspto-grants-2015_07 |
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| ORD ID | ord-28e1a0cde80d42b681fdf152d5961991 |
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| Source note | uspto-grants-2015_07 |
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