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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1528968Generated: November 4, 2026

1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-4-phenyl-butan-1-ol → 1-{4'-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-2-yl}-cyclopropanecarboxylic acid ethyl ester

https://huagongshe.com/reaction/1528968

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-4-phenyl-butan-1-olHCID 66578445—
Reactant1-[2-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid ethyl esterHCID 66579775—
Product1-{4'-[4-(1-Hydroxy-4-phenyl-butyl)-3-methyl-isoxazol-5-yl]-biphenyl-2-yl}-cyclopropanecarboxylic acid ethyl esterHCID 66578830—

Reaction Steps

Prepared according to the procedure described in Example 110, Step 3, using 1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-4-phenyl-butan-1-ol and 1-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid ethyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09090573B2
Source datasetuspto-grants-2015_07
ORD IDord-c31f3573cde046698f41626ecdd7e58f
Source noteuspto-grants-2015_07