5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde → 1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-pent-4-en-1-ol

HRID 1528974Notes

Reaction equation

HRID 1528974 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]=[O:15])=[CH:4][CH:3]=1.[CH2:16]([Mg]Br)[CH2:17][CH:18]=[CH2:19]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]([OH:15])[CH2:19][CH2:18][CH:17]=[CH2:16])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 821337925-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehydeHCID 178418797HCID 178418797, compound

Product 1

HCID 665821261-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-pent-4-en-1-ol

Procedure

Prepared according to the procedure described in Example 114, Step 3, using 5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde and 3-butenylmagnesium bromide.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-78d7154fc952401eba966edfbae7c0bf
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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