Benzyl acetone → [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-(1-methyl-3-phenyl-propyl)-amine

Participants

Role	Name	HCID	Charge
Reactant	Benzyl acetone	HCID 17355	—
Reactant	5-(4-Bromophenyl)-3-methylisoxazol-4-amine	HCID 58218537	—
Product	[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-(1-methyl-3-phenyl-propyl)-amine	HCID 66577220	—

Reaction Steps

Prepared according to the procedure described in Example 24, Step 1, using 5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylamine and 4-phenyl-butan-2-one. After the reaction the crude material was purified via preparatory chiral HPLC (Chiralcel-AD column, 2% EtOH in hexanes, 25 minutes) to afford two separate enantiomers. The first enantiomer eluted from the column is the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09090573B2
Source dataset	uspto-grants-2015_07
ORD ID	ord-59dfdf9b73db4f3986113b6cc3096448
Source note	uspto-grants-2015_07