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4-(2-Ethoxycarbonylethyl)benzeneboronic acid → 3-(4'-{3-Methyl-4-[1-methyl-3-(3-trifluoromethyl-phenyl)-propylamino]-isoxazol-5-yl}-biphenyl-4-yl)-propionic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(2-Ethoxycarbonylethyl)benzeneboronic acid | HCID 3851700 | — |
| 反応物 | [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-methyl-3-(3-trifluoromethyl-phenyl)-propyl]-amine | HCID 66577310 | — |
| 生成物 | 3-(4'-{3-Methyl-4-[1-methyl-3-(3-trifluoromethyl-phenyl)-propylamino]-isoxazol-5-yl}-biphenyl-4-yl)-propionic acid ethyl ester | HCID 66582115 | — |
反応手順
Prepared according to the procedure described in Example 1, Step 7, using [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-methyl-3-(3-trifluoromethyl-phenyl)-propyl]-amine (Enantiomer A) and [4-(2-ethoxycarbonylethyl)phenyl]boronic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09090573B2 |
| 出典データセット | uspto-grants-2015_07 |
| ORD ID | ord-c5897d3b40c0414fa3eb259d657881b7 |
| 出典メモ | uspto-grants-2015_07 |