4-(2-Ethoxycarbonylethyl)benzeneboronic acid → 3-(4'-{3-Methyl-4-[1-methyl-3-(3-trifluoromethyl-phenyl)-propylamino]-isoxazol-5-yl}-biphenyl-4-yl)-propionic acid ethyl ester

Participants

Role	Name	HCID	Charge
Reactant	4-(2-Ethoxycarbonylethyl)benzeneboronic acid	HCID 3851700	—
Reactant	[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-methyl-3-(3-trifluoromethyl-phenyl)-propyl]-amine	HCID 66577310	—
Product	3-(4'-{3-Methyl-4-[1-methyl-3-(3-trifluoromethyl-phenyl)-propylamino]-isoxazol-5-yl}-biphenyl-4-yl)-propionic acid ethyl ester	HCID 66582115	—

Reaction Steps

Prepared according to the procedure described in Example 1, Step 7, using [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-methyl-3-(3-trifluoromethyl-phenyl)-propyl]-amine (Enantiomer B) and [4-(2-ethoxycarbonylethyl)phenyl]boronic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09090573B2
Source dataset	uspto-grants-2015_07
ORD ID	ord-cab5a2ef9960462483c7a9e0c2798d8b
Source note	uspto-grants-2015_07