HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Chlorophenyl)butan-2-one → [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-[3-(3-chloro-phenyl)-1-methyl-propyl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Chlorophenyl)butan-2-one | HCID 260432 | — |
| Reactant | 5-(4-Bromophenyl)-3-methylisoxazol-4-amine | HCID 58218537 | — |
| Product | [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-[3-(3-chloro-phenyl)-1-methyl-propyl]-amine | HCID 66577294 | — |
Reaction Steps
Prepared according to the procedure described in Example 24, Step 1, using 5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylamine and 4-(3-chloro-phenyl)-butan-2-one. After silica gel chromatography the crude material was purified via preparatory chiral HPLC (Chiralcel-AD column, 1% EtOH in hexanes, 36 minutes) to afford two separate enantiomers. The first enantiomer eluted from the column is the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090573B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-2273c9586f5f48c5940e53fd917b24ae |
| Source note | uspto-grants-2015_07 |