Methyl 4-(4-bromophenyl)-4-oxobutanoate → HCID 66578167, compound

HRID 1529027Notes

Reaction equation

HRID 1529027 reaction equation
[CH3:1][C:2]1[C:6]([CH:7]([OH:17])[CH2:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:5]([C:18]2[CH:23]=[CH:22][C:21](B3OC(C)(C)C(C)(C)O3)=[CH:20][CH:19]=2)[O:4][N:3]=1.[CH3:33][O:34][C:35](=[O:47])[CH2:36][CH2:37][C:38]([C:40]1[CH:45]=[CH:44][C:43](Br)=[CH:42][CH:41]=1)=[O:39]>>[CH3:33][O:34][C:35](=[O:47])[CH2:36][CH2:37][C:38]([C:40]1[CH:41]=[CH:42][C:43]([C:21]2[CH:20]=[CH:19][C:18]([C:5]3[O:4][N:3]=[C:2]([CH3:1])[C:6]=3[CH:7]([OH:17])[CH2:8][CH2:9][CH2:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:23][CH:22]=2)=[CH:44][CH:45]=1)=[O:39]

Participants

3

Reactant 2

HCID 838865Methyl 4-(4-bromophenyl)-4-oxobutanoateHCID 66578361HCID 66578361, compound

Product 1

HCID 66578167HCID 66578167, compound

Procedure

Prepared according to the procedure described in Example 1, Step 7, using 1-{3-methyl-5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-isoxazol-4-yl}-4-phenyl-butan-1-ol and 4-(4-bromo-phenyl)-4-oxo-butyric acid methyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5985e5d3811943e2a55a80749382e86b
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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