5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde → 1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-3-methyl-3-phenyl-butan-1-ol

HRID 1529028Notes

Reaction equation

HRID 1529028 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]=[O:15])=[CH:4][CH:3]=1.[CH3:16][C:17]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)([CH3:21])[CH2:18][Mg]Cl>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]([OH:15])[CH2:16][C:17]([CH3:21])([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH3:18])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 821337925-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehydeHCID 178418740HCID 178418740, compound

Product 1

HCID 665820831-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-3-methyl-3-phenyl-butan-1-ol

Procedure

Prepared according to the procedure described in Example 114, Step 3, using 5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde and 2-methyl-2-phenylpropylmagnesium chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-03d8e189e8eb4d2ca56ea6748eeb9cd3
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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