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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1529032Generated: November 3, 2026

Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylate → 1-{4'-[4-(1-Hydroxy-2-phenethyloxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

https://huagongshe.com/reaction/1529032

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylateHCID 53217182—
Reactant1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-2-phenethyloxy-ethanolHCID 66577210—
Product1-{4'-[4-(1-Hydroxy-2-phenethyloxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl esterHCID 66577395—

Reaction Steps

Prepared according to the procedure described in Example 1, Step 7, using 1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-2-phenethyloxy-ethanol and 1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid ethyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09090573B2
Source datasetuspto-grants-2015_07
ORD IDord-6b23341327db4a60873462f865ee6e32
Source noteuspto-grants-2015_07