1-[(4-Bromophenyl)methyl]cyclopropanecarboxylic acid → HCID 66578660, compound

HRID 1529037Notes

Reaction equation

HRID 1529037 reaction equation
[CH3:1][C:2]1[C:6]([CH:7]([OH:17])[CH2:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:5]([C:18]2[CH:23]=[CH:22][C:21](B3OC(C)(C)C(C)(C)O3)=[CH:20][CH:19]=2)[O:4][N:3]=1.Br[C:34]1[CH:46]=[CH:45][C:37]([CH2:38][C:39]2([C:42]([OH:44])=[O:43])[CH2:41][CH2:40]2)=[CH:36][CH:35]=1>>[OH:17][CH:7]([C:6]1[C:2]([CH3:1])=[N:3][O:4][C:5]=1[C:18]1[CH:19]=[CH:20][C:21]([C:34]2[CH:46]=[CH:45][C:37]([CH2:38][C:39]3([C:42]([OH:44])=[O:43])[CH2:40][CH2:41]3)=[CH:36][CH:35]=2)=[CH:22][CH:23]=1)[CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 658114561-[(4-Bromophenyl)methyl]cyclopropanecarboxylic acidHCID 66578361HCID 66578361, compound

Product 1

HCID 66578660HCID 66578660, compound

Procedure

Prepared according to the procedure described in Example 1, Step 7, using 1-{3-methyl-5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-isoxazol-4-yl}-4-phenyl-butan-1-ol and 1-(4-bromo-benzyl)-cyclopropanecarboxylic acid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6c67014937f54e0e83b39afba0fa50fc
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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