{1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]cyclopropyl}-acetic acid ethyl ester → HCID 66582167, compound

HRID 1529092Notes

Reaction equation

HRID 1529092 reaction equation
[S:1]1[C:5]([CH:6]([NH:8][C:9]2[C:10]([CH3:21])=[N:11][O:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17](Br)=[CH:16][CH:15]=2)[CH3:7])=[CH:4][C:3]2[CH:22]=[CH:23][CH:24]=[CH:25][C:2]1=2.[CH2:26]([O:28][C:29](=[O:49])[CH2:30][C:31]1([C:34]2[CH:39]=[CH:38][C:37](B3OC(C)(C)C(C)(C)O3)=[CH:36][CH:35]=2)[CH2:33][CH2:32]1)[CH3:27]>>[CH2:26]([O:28][C:29](=[O:49])[CH2:30][C:31]1([C:34]2[CH:39]=[CH:38][C:37]([C:17]3[CH:18]=[CH:19][C:14]([C:13]4[O:12][N:11]=[C:10]([CH3:21])[C:9]=4[NH:8][CH:6]([C:5]4[S:1][C:2]5[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=5[CH:4]=4)[CH3:7])=[CH:15][CH:16]=3)=[CH:36][CH:35]=2)[CH2:33][CH2:32]1)[CH3:27]

Participants

3

Reactant 2

HCID 66578040{1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]cyclopropyl}-acetic acid ethyl esterHCID 66582176HCID 66582176, compound

Product 1

HCID 66582167HCID 66582167, compound

Procedure

Prepared according to the procedure described in Example 1, Step 7, using (1-benzo[b]thiophen-2-yl-ethyl)-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-amine and {1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropyl}-acetic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d45aa2dfecb7406598f9ff6bdedd757b
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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