Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Bromopyridine | HCID 12286 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | 1-[4'-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester | HCID 66577195 | — |
| Catalyst | (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium | HCID 6505921 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 66578796 | HCID 66578796 | — |
Reaction Steps
1-[4′-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester (0.200 g, 0.552 mmol) and 3-bromo-pyridine (0.087 g, 0.552 mmol) were dissolved in toluene along with Pd(dba)2 (0.032 g, 0.055 mmol), BINAP (0.069 g, 0.11 mmol) and cesium carbonate (0.270 g, 0.828 mmol). The reaction was heated to 110° C. overnight then allowed to cool. The reaction mixture was filtered through Celite then purified via preparatory HPLC to afford the title
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09090573B2 |
|---|
| Source dataset | uspto-grants-2015_07 |
|---|
| ORD ID | ord-cb8ce912133543abb1a3b071c8fd7930 |
|---|
| Source note | uspto-grants-2015_07 |
|---|
