1-[4'-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester → HCID 66578691, compound

HRID 1529112Notes

Reaction equation

HRID 1529112 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[NH2:27])=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH3:28][C:29]([CH3:42])([CH3:41])[CH2:30][NH:31][C:32]([C:34]1[CH:39]=[CH:38][CH:37]=[C:36](Br)[N:35]=1)=[O:33]>>[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[NH:27][C:36]4[CH:37]=[CH:38][CH:39]=[C:34]([C:32](=[O:33])[NH:31][CH2:30][C:29]([CH3:41])([CH3:28])[CH3:42])[N:35]=4)=[CH:17][CH:16]=3)=[CH:13][CH:14]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 665771951-[4'-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl esterHCID 85963447HCID 85963447, compound

Product 1

HCID 66578691HCID 66578691, compound

Procedure

Prepared according to the procedure described in Example 290, Step 1, using 1-[4′-(4-amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester and 6-bromo-pyridine-2-carboxylic acid (2,2-dimethyl-propyl)-amide.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-963d65482b5e4466a78aab8438b3fcdc
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

Loading…