HCID 56956917, compound → HCID 66582191, compound

HRID 1529121Notes

Reaction equation

HRID 1529121 reaction equation
[CH3:1][C:2]1[C:6]([NH:7][CH:8]([CH3:21])[CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=2)=[C:5]([C:22]2[CH:27]=[CH:26][C:25](B3OC(C)(C)C(C)(C)O3)=[CH:24][CH:23]=2)[O:4][N:3]=1.[CH2:37]([O:39][C:40](=[O:50])[C:41]#[C:42][C:43]1[CH:48]=[CH:47][C:46](Br)=[CH:45][CH:44]=1)[CH3:38]>>[CH2:37]([O:39][C:40](=[O:50])[C:41]#[C:42][C:43]1[CH:48]=[CH:47][C:46]([C:25]2[CH:26]=[CH:27][C:22]([C:5]3[O:4][N:3]=[C:2]([CH3:1])[C:6]=3[NH:7][CH:8]([CH3:21])[CH2:9][CH2:10][C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:19])([F:20])[F:18])[CH:12]=3)=[CH:23][CH:24]=2)=[CH:45][CH:44]=1)[CH3:38]

Participants

3

Reactant 2

HCID 56956917HCID 56956917, compoundHCID 66579781HCID 66579781, compound

Product 1

HCID 66582191HCID 66582191, compound

Procedure

Prepared according to the procedure described in Example 1, Step 7, using {3-methyl-5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-isoxazol-4-yl}-[1-methyl-3-(3-trifluoromethyl-phenyl)-propyl]-amine and (4-bromo-phenyl)-propynoic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8d7ec6b84e8f4166b0066f23b3f22c4c
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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