P-Toluenesulfonamide → HCID 66580175, compound

HRID 1529133Notes

Reaction equation

[CH3:1][C:2]1[C:6]([NH:7][C:8](O[C@H](C2C=CC=CC=2)C)=[O:9])=[C:5]([C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][C:28]([C:31]4([C:34](O)=[O:35])[CH2:33][CH2:32]4)=[CH:27][CH:26]=3)=[CH:21][CH:20]=2)[O:4][N:3]=1.[CH3:37][C:38]1[CH:39]=[CH:40][C:41]([S:44]([NH2:47])(=[O:46])=[O:45])=[CH:42][CH:43]=1>>[CH3:37][C:38]1[CH:39]=[CH:40][C:41]([S:44]([NH:47][C:34]([C:31]2([C:28]3[CH:29]=[CH:30][C:25]([C:22]4[CH:23]=[CH:24][C:19]([C:5]5[O:4][N:3]=[C:2]([CH3:1])[C:6]=5[NH:7][C:8]([NH:47][S:44]([C:41]5[CH:42]=[CH:43][C:38]([CH3:37])=[CH:39][CH:40]=5)(=[O:45])=[O:46])=[O:9])=[CH:20][CH:21]=4)=[CH:26][CH:27]=3)[CH2:32][CH2:33]2)=[O:35])(=[O:46])=[O:45])=[CH:42][CH:43]=1

Participants

Reactant 2

HCID 6269P-Toluenesulfonamide

HCID 49838688HCID 49838688, compound

Product 1

HCID 66580175HCID 66580175, compound

Procedure

Prepared according to the procedure described in Example 315 using 1-{4′-[3-Methyl-4-((S)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid and p-toluenesulfonamide.

Workup

customPrepared

Sources & evidence

ORD record: ord-7dfc76da66d24d0fb8c0f0c991604613
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09090573B2

Reaction notes

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