Cyclopropanesulfonamide → HCID 66578530, compound

HRID 1529134Notes

Reaction equation

[CH3:1][C:2]1[C:6]([NH:7][C:8](O[C@H](C2C=CC=CC=2)C)=[O:9])=[C:5]([C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][C:28]([C:31]4([C:34](O)=[O:35])[CH2:33][CH2:32]4)=[CH:27][CH:26]=3)=[CH:21][CH:20]=2)[O:4][N:3]=1.[CH:37]1([S:40]([NH2:43])(=[O:42])=[O:41])[CH2:39][CH2:38]1>>[CH:37]1([S:40]([NH:43][C:8](=[O:9])[NH:7][C:6]2[C:2]([CH3:1])=[N:3][O:4][C:5]=2[C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:26]=[CH:27][C:28]([C:31]4([C:34]([NH:43][S:40]([CH:37]5[CH2:39][CH2:38]5)(=[O:42])=[O:41])=[O:35])[CH2:32][CH2:33]4)=[CH:29][CH:30]=3)=[CH:21][CH:20]=2)(=[O:42])=[O:41])[CH2:39][CH2:38]1

Participants

Reactant 2

HCID 15765418Cyclopropanesulfonamide

HCID 49838688HCID 49838688, compound

Product 1

HCID 66578530HCID 66578530, compound

Procedure

Prepared according to the procedure described in Example 315 using 1-{4′-[3-Methyl-4-((S)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid and cyclopropanesulfonamide.

Workup

customPrepared

Sources & evidence

ORD record: ord-f6f4b4c27b3a45ef8c222c8b0fadee62
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09090573B2

Reaction notes

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