Cyclopropanesulfonamide → HCID 71004477, compound

HRID 1529145Notes

Reaction equation

[C:1]([Si:5]([CH3:42])([CH3:41])[O:6][CH:7]([C:17]1[C:18]([CH3:40])=[N:19][O:20][C:21]=1[C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][C:31]([C:34]3([C:37](O)=[O:38])[CH2:36][CH2:35]3)=[CH:30][CH:29]=2)=[CH:24][CH:23]=1)[CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([CH3:4])([CH3:3])[CH3:2].[CH:43]1([S:46]([NH2:49])(=[O:48])=[O:47])[CH2:45][CH2:44]1>>[C:1]([Si:5]([CH3:42])([CH3:41])[O:6][CH:7]([C:17]1[C:18]([CH3:40])=[N:19][O:20][C:21]=1[C:22]1[CH:23]=[CH:24][C:25]([C:28]2[CH:33]=[CH:32][C:31]([C:34]3([C:37]([NH:49][S:46]([CH:43]4[CH2:45][CH2:44]4)(=[O:48])=[O:47])=[O:38])[CH2:36][CH2:35]3)=[CH:30][CH:29]=2)=[CH:26][CH:27]=1)[CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([CH3:2])([CH3:4])[CH3:3]

Participants

Reactant 2

HCID 15765418Cyclopropanesulfonamide

HCID 66580035HCID 66580035, compound

Product 1

HCID 71004477HCID 71004477, compound

Procedure

Prepared according to the procedure described in Example 315 using 1-(4′-{4-[1-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid and cyclopropanesulfonamide.

Workup

customPrepared

Sources & evidence

ORD record: ord-6f26d22e4c9747ccafbc8f8ce939dbac
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09090573B2

Reaction notes

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