Methanesulfonamide → HCID 66579898, compound

HRID 1529151Notes

Reaction equation

[C:1]([Si:5]([CH3:43])([CH3:42])[O:6][CH:7]([C:17]1[C:18]([CH3:41])=[N:19][O:20][C:21]=1[C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][C:31]([C:34]3([CH2:37][C:38](O)=[O:39])[CH2:36][CH2:35]3)=[CH:30][CH:29]=2)=[CH:24][CH:23]=1)[CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:44][S:45]([NH2:48])(=[O:47])=[O:46]>>[C:1]([Si:5]([CH3:42])([CH3:43])[O:6][CH:7]([C:17]1[C:18]([CH3:41])=[N:19][O:20][C:21]=1[C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:29]=[CH:30][C:31]([C:34]3([CH2:37][C:38]([NH:48][S:45]([CH3:44])(=[O:47])=[O:46])=[O:39])[CH2:35][CH2:36]3)=[CH:32][CH:33]=2)=[CH:24][CH:23]=1)[CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([CH3:2])([CH3:4])[CH3:3]

Participants

Reactant 2

HCID 72879Methanesulfonamide

HCID 66578586HCID 66578586, compound

Product 1

HCID 66579898HCID 66579898, compound

Procedure

Prepared according to the procedure described in Example 315 using [1-(4′-{4-[1-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid and methanesulfonamide.

Workup

customPrepared

Sources & evidence

ORD record: ord-ebc00352c5cd41b9880c099764df6ca9
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09090573B2

Reaction notes

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