反应详情

30 ml of tert-butanol, 1.068 g (6.429 mmol) of methyl 3,3-dicyano-2,2-dimethylpropanoate dissolved in 15 ml of tert-butanol and 901 mg (8.037 mmol) of potassium tert-butoxide were added to 1.400 g (5.358 mmol) of 1-(cyclopentylmethyl)-5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide, and the mixture was heated under reflux for 24 h. The reaction mixture was concentrated on a rotary evaporator, triturated with 60 ml of water/ethanol (v/v=5:1), filtered off with suction and dried under high vacuum. This gave 1.296 g (57% of theory) of the target compound.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 24 h
3. concentrationThe reaction mixture was concentrated on a rotary evaporator
4. customtriturated with 60 ml of water/ethanol (v/v=5:1)
5. filtrationfiltered off with suction
6. customdried under high vacuum