Trifluoroacetic acid → HCID 71469258, compound

Participants

Reaction Conditions

Reaction Steps

96 mg (0.173 mmol) of the compound from Example 37A were stirred in dichloromethane (4 ml) and trifluoroacetic acid (1 ml) at room temperature for 4.5 h. The mixture was then concentrated to dryness. The residue was stirred in ethanol/2N hydrochloric acid (4:1, 15 ml) at 45° C. for 3 h. This was followed by concentration to dryness. Purification by preparative HPLC (methanol:water (+1% trifluoroacetic acid) gradient) gave 31 mg of the title compound (42% of theory).

Provenance & Evidence