5-Bromo-1-methyl-3-(5-(1-methylazetidin-3-yl)pyridin-2-ylamino)pyridine-2(1H)-one → 4-Fluoro-2-(1-methyl-5-(5-(1-methylazetidin-3-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridin-3-yl)-6-(1-oxo-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-2(1H)-yl)benzyl Acetate
Reaction equation
[Br:36][c:37]1[cH:38][c:39]([NH:45][c:46]2[n:47][cH:48][c:49]([CH:52]3[CH2:53][N:54]([CH3:56])[CH2:55]3)[cH:50][cH:51]2)[c:40](=[O:44])[n:41]([CH3:43])[cH:42]1.[C:1]([CH3:2])(=[O:3])[O:4][CH2:5][c:6]1[c:7]([B:27]2[O:28][C:29]([CH3:30])([CH3:31])[C:32]([CH3:33])([CH3:34])[O:35]2)[cH:8][c:9]([F:26])[cH:10][c:11]1[N:12]1[C:13](=[O:25])[c:14]2[n:15]([c:16]3[c:21]([cH:22]2)[CH2:20][CH2:19][CH2:18][CH2:17]3)[CH2:23][CH2:24]1>>[C:1]([CH3:2])(=[O:3])[O:4][CH2:5][c:6]1[c:7](-[c:37]2[cH:38][c:39]([NH:45][c:46]3[n:47][cH:48][c:49]([CH:52]4[CH2:53][N:54]([CH3:56])[CH2:55]4)[cH:50][cH:51]3)[c:40](=[O:44])[n:41]([CH3:43])[cH:42]2)[cH:8][c:9]([F:26])[cH:10][c:11]1[N:12]1[C:13](=[O:25])[c:14]2[n:15]([c:16]3[c:21]([cH:22]2)[CH2:20][CH2:19][CH2:18][CH2:17]3)[CH2:23][CH2:24]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-f8e30124ebdc41168f1d647e021a42bd
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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