Nitric Acid → HCID 178436894, compound

Participants

Reaction Steps

282.1 g (2.3 mol) 2-Ethyl-pyridin-4-ylamine are dissolved in concentrated HNO3 (789 mL, 11.561 mol) and H2O (1.5 L). Then a solution of NaNO2 (238.9 g, 3.468 mol) in H2O (600 mL) is slowly added to the solution over 2 h at 0° C. After the addition, the mixture is warmed to RT and stirred for additional 2 h. The reaction mixture is stored at −2° C. overnight. The precipitate is collected by filtration, and dried in vaccuo to afford the title compound. Yield: 155.1 g, (54%)

Provenance & Evidence