HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → HCID 49800788, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 58235232 | HCID 58235232 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | HCID 49800788 | HCID 49800788 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP5 starting from 120 mg (0.33 mmol) 4-[3-(6-Amino-pyridin-3-ylethynyl)-2-ethyl-pyridin-4-yl]-2-fluoro-benzoic acid (A-38) using 55 μL (0.50 mmoL) N-methyl piperazine, 139 mg (0.37 mmol) HATU and 96 μL DIPEA in 1.2 mL DMF. After completion of the reaction, the reaction mixture is filtered and the product is isolated from the obtained solution by RP-HPLC using a H2O/MeOH-gradient. Yield: 55 mg (37%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090564B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-d8d4b29a93cc4f0c8292917093ba070b |
| Source note | uspto-grants-2015_07 |