HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 49801085, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 1-(Oxan-4-yl)piperazine | HCID 21942315 | — |
| Reactant | HCID 58235232 | HCID 58235232 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | HCID 49801085 | HCID 49801085 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP5 starting from 320 mg (0.89 mmol) 4-[3-(6-Amino-pyridin-3-ylethynyl)-2-ethyl-pyridin-4-yl]-2-fluoro-benzoic acid (A-38) using 181 mg (1.06 mmoL) 1-tetrahydro-pyran-4-yl piperazine, 370 mg (0.97 mmol) HATU and 258 μL DIPEA in 3 mL DMF. After completion of the reaction, the reaction mixture is filtered and the product is isolated from the obtained solution by RP-HPLC using a H2O/MeOH-gradient. Yield: 90 mg (20%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090564B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-04370fb485974654837674042b592c91 |
| Source note | uspto-grants-2015_07 |